KCNQ2 Cure Alliance Research Roundtable 2026

KCNQ2 Cure Alliance Research Roundtable 2026

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7:30am CEST

Breakfast and Registration Centro Congressi Federico II

8:00am CEST

Welcome and Overview Centro Congressi Federico IIBrooke Babineau, PhD

8:15am CEST

Mapping KCNQ2 DEE: Disease Mechanisms, Channel Mislocalization, and Cortical Proteomic Signatures Centro Congressi Federico IIAnastasios Tzingounis, PhD • Maurizio Taglialatela, MD, PhD

8:30am CEST

Postsynaptic KCNQ Channels at Excitatory Synapses and Their Impact on Developmental and Epileptic Encephalopathy Centro Congressi Federico IIHee Jung Chung, PhD • Maurizio Taglialatela, MD, PhD

8:45am CEST

Panel Discussion and Q&A Centro Congressi Federico IIMaurizio Taglialatela, MD, PhD

9:00am CEST

Gene Therapy for KCNQ2 DEE Centro Congressi Federico IIYong Cheng, PhD • Maurizio Taglialatela, MD, PhD

9:15am CEST

Development and Evaluation of Systemic AAV Gene Therapy to Treat Neonatal KCNQ2 Epileptic Encephalopathy Centro Congressi Federico IIRana Eser, PhD • Maurizio Taglialatela, MD, PhD

9:30am CEST

Targeted Approach for KCNQ2-DEE With a Novel Engineered AAV Gene Therapy Centro Congressi Federico IINick Goeden, PhD • Maurizio Taglialatela, MD, PhD

9:45am CEST

Panel Discussion and Q&A Centro Congressi Federico IIMaurizio Taglialatela, MD, PhD

10:00am CEST

Break Centro Congressi Federico II

10:15am CEST

QRL-101: A Kv7.2/7.3 Modulator for the Treatment of Rare Epilepsy Centro Congressi Federico IIManoj Malhotra • Maurizio Taglialatela, MD, PhD

10:30am CEST

Toward Scalable Precision Therapeutics for KCNQ2-DEE Centro Congressi Federico IIAubrie Soucy Verran, MLA • Maurizio Taglialatela, MD, PhD

10:45am CEST

Antisense Oligonucleotide Treatment: Application of the N-of-1 Paradigm Centro Congressi Federico IITristan Sands, MD, PhD • Maurizio Taglialatela, MD, PhD

11:00am CEST

Extended Discussion: Delivering Treatments to Patients (Breakout Groups: Small Molecule, ASO, Gene Therapy) Centro Congressi Federico IIMaurizio Taglialatela, MD, PhD

11:45am CEST

Lunch and Posters Centro Congressi Federico II

1:15pm CEST

Patient Registries vs. Natural History Studies: What’s the Difference? Centro Congressi Federico IIIngrid Scheffer, AO, MB, BS, PhD, FRACP, FAHMS, FAA • Anastasios Tzingounis, PhD

1:45pm CEST

European KCNQ2 Research: Biomarkers, Natural History, and Therapeutic Development Centro Congressi Federico IISarah Weckhuysen, MD, PhD • Anastasios Tzingounis, PhD

2:15pm CEST

Natural History and Registries: A Call to Action Centro Congressi Federico IIIsabella Brambilla • Maurizio Taglialatela, MD, PhD

2:45pm CEST

Extended Discussion: KCNQ2 Coordination and Facilitating Global Collaboration on Registries and Natural History Studies Centro Congressi Federico II

3:15pm CEST

Break Centro Congressi Federico II

3:30pm CEST

Antisense Oligonucleotides for KCNQ2 Centro Congressi Federico IISteven Petrou, PhD • Anastasios Tzingounis, PhD

4:00pm CEST

From Channel Biophysics to Neuronal Excitability: Mechanisms of KCNQ Dysfunction in Neurodevelopmental Disorders Centro Congressi Federico IIRene Barro-Soria, PhD • Anastasios Tzingounis, PhD

4:15pm CEST

A Framework for Quantitative Motor Phenotyping in KCNQ2-Related Neurodevelopmental Disorders Centro Congressi Federico IISunanjay Bajaj, MD • Anastasios Tzingounis, PhD

4:30pm CEST

Establishing a Humanized KCNQ2 p.G281R Mouse as a Preclinical Model for Therapeutic Discovery Centro Congressi Federico IIAnil Aturk, PhD • Anastasios Tzingounis, PhD

4:45pm CEST

Panel Discussion and Q&A Centro Congressi Federico IIAnastasios Tzingounis, PhD

5:00pm CEST

Wrap-Up and Thanks Centro Congressi Federico IIBrooke Babineau, PhD