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KCNQ2 Cure Alliance Research Roundtable 2026
KCNQ2 Cure Alliance Research Roundtable 2026
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Saturday
, September 19
Centro Congressi Federico II
7:30am •
Breakfast and Registration
8:00am •
Welcome and Overview
8:15am •
Mapping KCNQ2 DEE: Disease Mechanisms, Channel Mislocalization, and Cortical Proteomic Signatures
8:30am •
Postsynaptic KCNQ Channels at Excitatory Synapses and Their Impact on Developmental and Epileptic Encephalopathy
8:45am •
Panel Discussion and Q&A
9:00am •
Gene Therapy for KCNQ2 DEE
9:15am •
Development and Evaluation of Systemic AAV Gene Therapy to Treat Neonatal KCNQ2 Epileptic Encephalopathy
9:30am •
Targeted Approach for KCNQ2-DEE With a Novel Engineered AAV Gene Therapy
9:45am •
Panel Discussion and Q&A
10:00am •
Break
10:15am •
QRL-101: A Kv7.2/7.3 Modulator for the Treatment of Rare Epilepsy
10:30am •
Toward Scalable Precision Therapeutics for KCNQ2-DEE
10:45am •
Antisense Oligonucleotide Treatment: Application of the N-of-1 Paradigm
11:00am •
Extended Discussion: Delivering Treatments to Patients (Breakout Groups: Small Molecule, ASO, Gene Therapy)
11:45am •
Lunch and Posters
1:15pm •
Patient Registries vs. Natural History Studies: What’s the Difference?
1:45pm •
European KCNQ2 Research: Biomarkers, Natural History, and Therapeutic Development
2:15pm •
Natural History and Registries: A Call to Action
2:45pm •
Extended Discussion: KCNQ2 Coordination and Facilitating Global Collaboration on Registries and Natural History Studies
3:15pm •
Break
3:30pm •
Antisense Oligonucleotides for KCNQ2
4:00pm •
From Channel Biophysics to Neuronal Excitability: Mechanisms of KCNQ Dysfunction in Neurodevelopmental Disorders
4:15pm •
A Framework for Quantitative Motor Phenotyping in KCNQ2-Related Neurodevelopmental Disorders
4:30pm •
Establishing a Humanized KCNQ2 p.G281R Mouse as a Preclinical Model for Therapeutic Discovery
4:45pm •
Panel Discussion and Q&A
5:00pm •
Wrap-Up and Thanks
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Via Partenope, 36, Naples, Metropolitan City of Naples, Italy
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Centro Congressi Federico II
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Session 1: Mislocalization
Session 2: Therapeutics I
Session 3: Therapeutics II
Session 4: Natural History and Registries
Session 5: Special Topics
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Rohan Seth
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Saturday
, September 19
Session Type
Break
Breakfast
All
Subtype1
Subtype2
Lunch
Session 1: Mislocalization
Session 2: Therapeutics I
Session 3: Therapeutics II
Session 4: Natural History and Registries
Session 5: Special Topics
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